The 'Reset'Р”В«utton is used to set the most recent time period with a length of 30 years (4). Only the data of the selected period is processed and displayed in the climate chart.

The upper and lower limits (3) of the light grey bar. The selected time period can be adjusted individually by moving The maximumР”Р„vailable time period for the selected data set (2) is shown in white. Maximum time period in which data (independent of the selected dataset) is available. The web applicationР”В¬ offers the possibility to adapt this period according to your own requirements.Р”Р‡or this purpose, a slider for adjusting the period (1) is available. 1.3.2 Time PeriodР”В¬limate diagrams are often generated for a period of at least 30 years. You can find more information about the datasets in the menu 'Datasets & Software'. The selection menu is located beneath the map.Р”Р„fter you have chosen the preferred data set, you can select a location in the map. One of these data sets before clicking on a location in the map.

In addition, three different raster data sets can be used to generate climate diagrams. This data set is automatically selected whenever a user clicks on a station (cf. The weather stationsРІР‚в„ў data set is part of the Global Historical Climatology Network (GHCN). Overall, four data sets are available for the generation of climate charts. This popup alsoР”В¬ontains information about the name of the place you have selected (3) as well as information about the climateР”В¬lasses according to KР“В¶ppen-Geiger, the altitude and the selected time period (4). You can also see that you have selected a station by the note 'Climate Station' in the popup (2). If you click on one of the brown marked dots on the map, a weather station is selected. With theР”В«utton 'Create Charts' a diagram is created below the map (5). This popup also contains information about the name of the place you have selected (3) as well as informationР”Р„bout the climate classes according to KР“В¶ppen-Geiger, the altitude and the selected time period (4). Another indicator that youР”Р„re seeing raster instead of station data is the note 'Climate Cell' at the top of the information popup (2). Within this grid cell the resulting climate diagrams are identical. Once you selected a raster data set and clicked on a location, the corresponding raster cell is shown on the In this case a raster cell at this position is selected. In addition, it is also possible to select a position on the map by entering coordinates into the filter menu. There are two types of data sets available - raster data (see 1.2.1) and station data (see 1.2.2). The coiled-coil interaction motif thus provides a molecular explanation for the functional aggregation of SFPQ that directs its role in regulating many aspects of cellular nucleic acid metabolism.The selection of a location is quite easy and is done by clicking on a position in the map. We demonstrate that the ability to polymerize is essential for the cellular functions of SFPQ: disruptive mutation of the coiled-coil interaction motif results in SFPQ mislocalization, reduced formation of nuclear bodies, abrogated molecular interactions and deficient transcriptional regulation. Small-angle X-ray scattering and transmission electron microscopy experiments show that polymerization is reversible in solution and can be templated by DNA. Here we describe the first crystal structures of Splicing Factor Proline and Glutamine Rich (SFPQ), revealing structural similarity to the related PSPC1/NONO heterodimer and a strikingly extended structure (over 265 Р“вЂ¦ long) formed by an unusual anti-parallel coiled-coil that results in an infinite linear polymer of SFPQ dimers within the crystals. PSF), is a human tumor suppressor protein that regulates many important functions in the cell nucleus including coordination of long non-coding RNA molecules into nuclear bodies.

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